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Daxx (phospho-S668) polyclonal antibody（KU）

货号: BS4227

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS4227

Product Name :Daxx (phospho-S668) polyclonal antibody（KU）

Swiss-Prot :Q9UER7

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Apoptosis, or programmed cell death, occurs duringnormal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD) containing adapter molecules and members of the ICE/CED3 protease family. A novel DD containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx is a death domain containing important intermediate in the Fas mediated apoptosis. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N terminal kinase (JNK) pathway. It is widely expressed in fetal and adult human and mouse tissue, indicating its important function in Fas signaling pathways.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Daxx (phospho-S668) polyclonal antibodydetects endogenous levels of Daxx protein only when phosphorylated at Ser668.

BiowMW :~ 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Death Receptor Signaling,

Alternative Name :Death domain-associated protein 6; Daxx; hDaxx; ETS1-associated protein 1; EAP1; Fas death domain-associated protein; BING2; DAP6; DAXX

Immunogen :Synthetic phosphopeptide derived from human Daxx around the phosphorylation site of Serine 668.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot (WB) analysis of p-Daxx (S668) pAb at 1:500 dilution Lane1:A2780 whole cell lysate(40ug) Lane2:Hela whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug) Lane4:K562 whole cell lysate(20ug)