Product Name :ABL1/2 (phospho-Y393/439) polyclonal antibody
Swiss-Prot :P00519/P42684
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :p-ABL1/2 (Y393/439) polyclonal antibody detects endogenous levels of ABL1 protein only when phosphorylated at Tyr393 and ABL2 protein only when phosphorylated at Tyr439.
Note :For research use only, not for use in diagnostic procedure.
Pathway :SAPK JNK Signaling Cascades,
Alternative Name :Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150; ABL1; ABL; JTK7; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG; ABL2; ABLL; ARG
Immunogen :Synthetic phosphopeptide derived from human ABL1/2 around the phosphorylation site of Tyrosine 393/439.
Modification :Phosphorylation
