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HDAC5 (phospho-S498) polyclonal antibody（KU）

货号: BS4086

价格：￥ 1350

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS4086

Product Name :HDAC5 (phospho-S498) polyclonal antibody（KU）

Swiss-Prot :Q9UQL6

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :HDAC5 is a member of the class II mammalian histone deacetylase family, which is structurally related to yeast HDA1. Human HDAC5 is composed of 1122 amino acid residues. The deacetylase domain of HDAC5 is located at the C-terminal half of the molecule. The N-terminal non-deacetylase domain does not show any significant homology with any published sequence.Both domains are required for HDAC5-mediated repression of gene transcription. HDAC5 interacts with a growing number of transcriptional factors including MEF2A as well as other HDAC proteins. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-HDAC5 (S498) polyclonal antibody detects endogenous levels of HDAC5 protein only when phosphorylated at Ser498.

BiowMW :~ 140 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Notch Signaling,Nuclear Receptor Signaling,Cell Cycle Control G1 S Checkpoint,Epigenetic Writers and Erasers of Histone H3,Epigenetic Writers and Erasers of Histones H2A H2B and H4,

Alternative Name :Histone deacetylase 5; Short name=HD5; Antigen NY-CO-9; HDAC-5; KIAA0600

Immunogen :Synthetic phosphopeptide derived from human HDAC5 around the phosphorylation site of Serine 498.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot (WB) analysis of p-HDAC5 (S498) pAb at 1:1000 dilution Lane1:The Uterus tissue lysate of Rat(40ug) Lane2:BV2 whole cell lysate(40ug) Lane3:C6 whole cell lysate(40ug) Lane4:HEK293T whole cell lysate(40ug) Lane5:Hela whole cell lysate(40ug) Lane6:U-87MG whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of p-HDAC5 (S498) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.