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AR (phospho-S650) polyclonal antibody

货号: BS4012

价格：￥ 780

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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详细信息检测数据实验指南文献

No. :BS4012

Product Name :AR (phospho-S650) polyclonal antibody

Swiss-Prot :P10275

Host :Rabbit

Reactivity :Human,Rat

Applications :IHC

Application_all :IHC: 1:50~1:200

Background :Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and reproductive physiology in males. The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. ARs bind active testosterone (T) and dihydrotestosterone (DHT). The rates of association and dissociation of T are about 3 times more rapid than those of DHT. This difference in binding kinetics may account for the different physiological effects of T and DHT. Androgen binding results in an at least 6-fold increase in androgen receptor stability.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-AR (S650) polyclonal antibody detects endogenous levels of Androgen Receptor protein only when phosphorylated at Ser650 .

BiowMW :~ 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Nuclear Receptor Signaling,

Alternative Name :Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4; AR; DHTR; NR3C4

Immunogen :Synthetic phosphopeptide derived from human AR around the phosphorylation site of Serine 650.

Conjugate :Unconjugated

Modification :Phosphorylation

Immunohistochemistry (IHC) analyzes of p-AR (S650) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

免疫沉淀（IP）

免疫组织化学（IHC）