Product Name :AR (phospho-S213) polyclonal antibody
Application_all :IHC: 1:50~1:200
Background :Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and reproductive physiology in males. The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. ARs bind active testosterone (T) and dihydrotestosterone (DHT). The rates of association and dissociation of T are about 3 times more rapid than those of DHT. This difference in binding kinetics may account for the different physiological effects of T and DHT. Androgen binding results in an at least 6-fold increase in androgen receptor stability.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :p-AR (S213) polyclonal antibody detects endogenous levels of Androgen Receptor protein only when phosphorylated at Ser213.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Nuclear Receptor Signaling,
Alternative Name :Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4; AR; DHTR; NR3C4
Immunogen :Synthetic phosphopeptide derived from human AR around the phosphorylation site of Serine 213.
Modification :Phosphorylation
