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Glut 4 (R271) polyclonal antibody（KU）

货号: BS3680

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS3680

Product Name :Glut 4 (R271) polyclonal antibody（KU）

Swiss-Prot :P14672

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :In response to insulin, Glut4 is quickly shuttled from an intracellular storage site to the plasma membrane, where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane and shows a much less dramatic translocation in response to insulin. Glut1 and Glut4 are twelve pass transmembrane proteins (12TM) whose carboxy-termini may dictate their cellular localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 null mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellular glucose, fat metabolism and prolonged longevity.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Glut4 (R271) polyclonal antibody detects endogenous levels of Glut4 protein.

BiowMW :~ 45-55 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Warburg Effect,Insulin &Glucose Signaling,

Alternative Name :Solute carrier family 2; facilitated glucose transporter member 4; Glucose transporter type 4; insulin-responsive; GLUT-4; GLUT4; SLC2A4

Immunogen :Synthetic peptide, corresponding to amino acids 250-300 of Human Glut 4.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of Glut 4 (R271) pAb at 1:500 dilution Lane1:The Heart tissue lysate of Mouse(40ug) Lane2:The Heart tissue lysate of Rat(20ug) Lane3:MCF-7 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Glut 4 (R271) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Differential expression of the glucose transporters in mouse gustatory papillae

JournalCell And Tissue Research

ApplicationWB,IF,IHC

IF4.044

SpeciesMouse

PMID21739243
Protective effect of β-casomorphin-7 on cardiomyopathy of streptozotocin-induced diabetic rats via inhibition of hyperglycemia and oxidative stress

JournalPeptides

ApplicationWB

IF3.75

SpeciesRat

PMID
Overexpression of mitofusin 2 improves translocation of glucose transporter 4 in skeletal muscle of high‑fat diet‑fed rats through AMP‑activated protein kinase signaling

JournalMolecular Medicine Reports

ApplicationWB

IF2.952

SpeciesRat

PMID
Curcumin regulates cell fate and metabolism by inhibiting hedgehog signaling in hepatic stellate cells

JournalLaboratory Investigation

ApplicationFC,IF,WB

IF3.684

SpeciesRat

PMID25938627
Epigenetic regulation of placental glucose transporters mediates maternal cadmium-induced fetal growth restriction

JournalToxicology

ApplicationWB

IF3.547

SpeciesMouse

PMID27931521