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eIF2α (I45) polyclonal antibody（KU）

货号: BS3651

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS3651

Product Name :eIF2α (I45) polyclonal antibody（KU）

Swiss-Prot :P05198

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :eIF2α, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2α controls the rate of tRNA translation. When eIF2α is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2α is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :eIF2α (I45) polyclonal antibody detects endogenous levels of eIF2α protein.

BiowMW :~ 38 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Translational Contral Regulation of elF2,

Alternative Name :Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha; EIF2A; EIF2S1

Immunogen :Synthetic peptide, corresponding to amino acids 11-60 of Human eIF2α.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of eIF2α (I45) polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate(40ug) Lane2:H9C2 whole cell lysate(40ug) Lane3:Hela whole cell lysate(40ug) Lane4:NIH-3T3 whole cell lysate(40ug) Lane5:PC12 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of eIF2α (I45) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

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