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FKHR/FoxO1 (F313) polyclonal antibody

货号: BS3573

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3573

Product Name :FKHR/FoxO1 (F313) polyclonal antibody

Swiss-Prot :Q12778

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :FOXO1A (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein which is a member of a subfamily of the forkhead homeotic gene family of transcription factors. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Chromosomal aberrations involving FOXO1A are a cause of rhabdomyosarcoma 2 (RMS2); also known as alveolar rhabdomyosarcoma.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :FoxO1 (F313) polyclonal antibody detects endogenous levels of FoxO1 protein.

BiowMW :~ 70 to 82 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :PI3K AKT signaling,Insulin &Glucose Signaling,

Alternative Name :Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; FOXO1; FKHR; FOXO1A

Immunogen :Synthetic peptide, corresponding to amino acids 300-350 of Human FKHR/FoxO1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of FoxO1 (F313) pAb at 1:1000 dilution Lane1:H1792 whole cell lysate(40ug) Lane2:3T3-L1 whole cell lysate(40ug) Lane3:C6 whole cell lysate(20ug) Lane4:HEK293T whole cell lysate(20ug)

Immunohistochemistry (IHC) analyzes of FKHR/FoxO1 (F313) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.