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ApoE (M86) polyclonal antibody

货号: BS3550

价格：￥ 660

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS3550

Product Name :ApoE (M86) polyclonal antibody

Swiss-Prot :P02649

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :IHC

Application_all :IHC: 1:50~1:200

Background :Apolipoprotein-E (ApoE) is a protein component of plasma lipoproteins that mediates the binding, internalization and catabolism of lipoprotein particles. It can serve as a ligand for several lipoprotein receptors, including the LDL (apoB/E) receptor and the hepatic apoE (chylomicron remnant) receptor. apoE is produced in most organs and occurs in all plasma lipoprotein fractions, constituting 10-20% of VLDL (very low density lipoprotein) and 1-2% of HDL (high density lipoprotein). Three major isoforms of apoE have been described in human (E2, E3 and E4) which differ by one to two amino acids. Estrogen receptor has been shown to upregulate apoE gene expression via the ERamediated pathway, indicating a potential role for apoE in atherosclerosis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ApoE (M86) polyclonal antibody detects endogenous levels of ApoE protein.

BiowMW :~ 36 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Neuronal and Glial Cell Marker Atlas,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,

Alternative Name :Apolipoprotein E; Apo-E; APOE

Immunogen :Synthetic peptide, corresponding to amino acids 51-100 of Human ApoE.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry (IHC) analyzes of ApoE (M86) pAb in paraffin-embedded human lung carcinoma tissue at 1:50.showing secreted staining. Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.