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ACE (F940) polyclonal antibody（KU）

货号: BS3485

价格：￥ 660

货期：现货（1-2个工作日）

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No. :BS3485

Product Name :ACE (F940) polyclonal antibody（KU）

Swiss-Prot :P12821

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Angiotensin-converting enzyme (ACE) is a carboxy-terminal dipeptidyl exo-peptidase that converts Angiotensin I to the potent vasopressive hormone, Angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically, late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in fluid/electrolyte homeostasis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ACE (F940) polyclonal antibody detects endogenous levels of Angiotensin-converting enzyme protein.

BiowMW :~ 170 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Angiotensin-converting enzyme; Short name=ACE; Dipeptidyl carboxypeptidase I; CD143; ACE1; DCP; DCP1; Angiotensin Converting Enzyme 1

Immunogen :Synthetic peptide, corresponding to amino acids 920-950 of Human ACE.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of ACE (F940) pAb at 1:500 dilution Lane1:PC3 whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:SGC7901 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of ACE (F940) pAb bin paraffin-embedded human kidney carcinoma tissue at 1:50,showing cytoplasmic and membrane staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Sex dimorphism in ANGII-mediated crosstalk between ACE2 and ACE in diabetic nephropathy

JournalLaboratory Investigation

ApplicationIHC

IF5.662

SpeciesMouse

PMID29884907
Aortic remodelling induced by obstructive apneas is normalized with mesenchymal stem cells infusion

JournalScientific Reports

ApplicationWB

IF4.379

SpeciesRat

PMID31391506
The ACE2 activator diminazene aceturate ameliorates colitis by repairing the gut-vascular barrier in mice

JournalMICROVASCULAR RESEARCH

ApplicationWB

IF3.75

SpeciesMouse

PMID37127063