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ABCG2 (N338) polyclonal antibody（KU）

货号: BS3482

价格：￥ 660

货期：现货（1-2个工作日）

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No. :BS3482

Product Name :ABCG2 (N338) polyclonal antibody（KU）

Swiss-Prot :Q9UNQ0

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :ABCG2, is also known as placenta-specific ABC transporter and breast cancer resistance protein (BCRP1). ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Under normal conditions, ABCG2 may serve a protective function by removing toxins from the cell, and plays an important role in regulating stem cell differentiation. ABCG2 is responsible for the side population (SP) phenotype and is widely expressed in a large variety of stem cells, making it an important stem cell marker. ABCG2 may have N-linked glycosylation and may dimerize in vivo. ABCG2 is abundantly expressed in placenta, liver, intestine and stem cells.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ABCG2 (N338) polyclonal antibody detects endogenous levels of ATP-binding cassette sub-family G member 2 protein.

BiowMW :~ 72 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter; CD338; ABCP; BCRP; BCRP1; MXR

Immunogen :Synthetic peptide, corresponding to amino acids 302-356 of Human ABCG2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ABCG2 (N338) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate Lane3:H9C2 cell lysate

Immunohistochemistry (IHC) analyzes of ABCG2 (N338) pAb in paraffin-embedded human lung carcinoma tissue at 1:50,showing cytoplasmic staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Immunohistochemistry (IHC) analyzes of ABCG2 (N338) pAb in paraffin-embedded human rectum carcinoma tissue at 1:50,showing cytoplasmic staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Ivermectin induces chicken BCRP/ABCG2 expression and function: Involvement of CXR signaling pathway and mRNA stabilization

JournalJOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

ApplicationWB

IF1.567

SpeciesChicken

PMID35924758
Chicken xenobiotic receptor upregulates the BCRP/ABCG2 transporter

JournalPOULTRY SCIENCE

ApplicationWB

IF4.014

SpeciesChicken

PMID36402040
Curcumin Affects the Pharmacokinetics of Florfenicol by Downregulating the Expression of BCRP in Poultry

JournalJOURNAL OF APPLIED POULTRY RESEARCH

ApplicationWB

IF1.9

SpeciesChicken

PMID