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AGER / RAGE (E182) polyclonal antibody

货号: BS3448

价格：￥ 660

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS3448

Product Name :AGER / RAGE (E182) polyclonal antibody

Swiss-Prot :Q15109

Host :Rabbit

Reactivity :Human

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Advanced glycosylation end products of proteins (AGEs) are nonenzymatically glycosylated proteins that are associated with a variety of conditions, including diabetes and other vascular disorders, as well as amyloidosis. These proteins regulate cellular functions via specific cell surface acceptor molecules, such as RAGE (receptor for advanced glycosylation end products). RAGE is a type 1 membrane protein that is found on the surface of endothelial cells, mononuclear phagocytes and vascular smooth muscle cells. Binding of AGEs to RAGE results in the induction of cellular oxidant stress and activation of the transcription factor NFkB. Evidence suggests that the induction of oxidant stress results in the activation of an intracellular cascade involving p21 ras and MAP kinase, which leads to activation of transcription.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AGER (E182) polyclonal antibody detects endogenous levels of AGER protein.

BiowMW :~43 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Receptor for advanced glycosylation end products; Advanced glycosylation end product-specific receptor; AGER; RAGE

Immunogen :Synthetic peptide, corresponding to amino acids 150-205 of Human AGER / RAGE.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of RAGE (E182) polyclonal antibody in extracts from HEK293A cells.

MRP8/14 mediates macrophage efferocytosis through RAGE and Gas6/MFG‐E8, and induces polarization via TLR4‐dependent pathway

JournalJournal Of Cellular Physiology

Application

IF5.546

Species

PMID33128793