Product Name :mGluR-2/3 (N867) polyclonal antibody
Swiss-Prot :Q14416/Q14832
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :The mGluR proteins (metabotropic Glutamate Receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :mGluR-2/3 (N867) polyclonal antibody detects endogenous levels of mGluR-2 and mGluR-3 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Metabotropic glutamate receptor 2; mGluR2; GRM2; GPRC1B; MGLUR2; Metabotropic glutamate receptor 3; mGluR3; GRM3; GPRC1C; MGLUR3
Immunogen :Synthetic peptide, corresponding to amino acids 836-886 of Human mGluR-2.
Modification :Unmodification
