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FTβ (E285) polyclonal antibody（KU）

货号: BS3377

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3377

Product Name :FTβ (E285) polyclonal antibody（KU）

Swiss-Prot :P49356

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Mammalian protein farnesyl transferases are heterodimeric proteins containing two nonidentical α and β subunits that attach farnesyl residues to a cysteine at the fourth position from the COOH terminus of several proteins, including nuclear lamins and p21Ras proteins. The natural substrates contain the Cys-A-A-Xaa recognition sequence, where the A residues are aliphatic and Xaa represents methionine, serine, glutamine or cysteine. The purified farnesyl transferase is an a-b heterodimer. The β subunit, which is known as FTβ, CAAX farnesyltransferase subunit β, or Ras proteins prenyltransferase subunit β, is a 437 amino acid protein that contains five PFTB repeats and binds the peptide substrate. The α subunit is suspected to participate in formation of a stable complex with the substrate farnesyl pyrophosphate.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :FTβ (E285) polyclonal antibody detects endogenous levels of FTβ protein.

BiowMW :~ 48 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Protein farnesyltransferase subunit beta; FTase-beta; FTase-β; FTase β; CAAX farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta; FNTB

Immunogen :Synthetic peptide, corresponding to amino acids 250-300 of Human FTβ.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of FTβ (E285) pAb at 1:500 dilution Lane1:A549 whole cell lysate(40ug) Lane2:PC3 whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug) Lane4:SGC7901 whole cell lysate(40ug) Lane5:L02 whole cell lysate(40ug)