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GNL1 (Q103) polyclonal antibody（KU）

货号: BS3312

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS3312

Product Name :GNL1 (Q103) polyclonal antibody（KU）

Swiss-Prot :P36915

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :GNL1 (guanine nucleotide-binding protein-like 1) is a nuclear protein that likely acts as a regulator of the histocompatibility cluster. GNL1 and MMR1, the murine homolog, are localized within or close to the MHC class I region and belong to the MMR1/HSR1 GTP-binding protein family. GTPases, such as GNL1, from the MMR1/HSR1 GTP-binding protein subfamily are circularly rearranged G-motifs that play a critical role in maintaining normal cell growth. Deletion of these genes results in severe growth defects with a marked reduction in mature rRNA species and a concomitant accumulation of the 35S pre-rRNA transcript. Deletion also causes the ribosomal protein RPL25A to fail exportation from the nucleolus. Deletion of any of the G-domain motifs will result in a null phenotype and nuclear/nucleolar localization that lacks the nucleolar export of preribosomes and is accompanied by a distortion of the nucleolar structure. Upon DNA damage GNL1 is phosphorylated by a kinase, possibly Atm or ATR.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :GNL1 (Q103) polyclonal antibody detects endogenous levels of GNL1 protein.

BiowMW :~ 69 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Guanine nucleotide-binding protein-like 1; GTP-binding protein HSR1; GNL1; HSR1

Immunogen :Synthetic peptide, corresponding to amino acids 80-120 of Human GNL1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of GNL1 (Q103) pAb at 1:1000 dilution Lane1:The Brain tissue lysate of Mouse(40ug) Lane2:The Brain tissue lysate of Rat(40ug) Lane3:HEK293T whole cell lysate(40ug) Lane4:MCF-7 whole cell lysate(40ug)