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GCP5 (I779) polyclonal antibody（KU）

货号: BS3303

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3303

Product Name :GCP5 (I779) polyclonal antibody（KU）

Swiss-Prot :Q96RT8

Host :Rabbit

Reactivity :Human

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The γ-Tubulin complex is composed of γ Tubulin and the γ-Tubulin complexassociated proteins GCP2, GCP3, GCP4, GCP5 and GCP6, all of which are essential components of microtubule organizing centers. γ-Tubulin complex components are localized to both the centrosome, where they are involved in microtubule nucleation, and to the cytoplasm, where they exist as soluble complexes that can be recruited to the centrosome as needed. Although the GCP proteins are related, they have distinct roles which contribute to the proper function of the γ-Tubulin complex. GCP5 (γ-Tubulin complex component 5), also known as TUBGCP5, is a 1,024 amino acid member of the γ-Tubulin complex and is highly expressed in heart and skeletal muscle. Defects in the gene encoding GCP5 are implicated in Prader-Willi syndrome (PWS), a rare genetic disorder associated with obesity, compulsive behavior and lower intellectual ability.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :GCP5 (I779) polyclonal antibody detects endogenous levels of GCP5 protein.

BiowMW :~ 118 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Gamma-tubulin complex component 5; GCP-5; TUBGCP5; GCP5; KIAA1899

Immunogen :Synthetic peptide, corresponding to amino acids 746-794 of Human GCP5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of GCP5 (I779) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:L02 whole cell lysate(40ug) Lane3:SGC7901 whole cell lysate(20ug) Lane4:A375 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of GCP5 (I779) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.

MZT1 regulates microtubule nucleation by linking γTuRC assembly to adapter-mediated targeting and activation

JournalJournal Of Cell Science

ApplicationWB

IF4.517

SpeciesHuman

PMID27852835