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FBP3 (R241) polyclonal antibody（KU）

货号: BS3297

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS3297

Product Name :FBP3 (R241) polyclonal antibody（KU）

Swiss-Prot :Q96I24

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Activation of FUSE, the far-upstream element, is required for the proper expression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP (FUSE-binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL60 cells, FBP, FBP2, and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxylterminal activation domains. Expression of FBP is detected in undifferentiated cells and is substantially decreased following cellular differentiation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :FBP3 (R241) polyclonal antibody detects endogenous levels of FBP3 protein.

BiowMW :~ 60 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Far upstream element-binding protein 3; FUSE-binding protein 3; FUBP3; FBP3

Immunogen :Synthetic peptide, corresponding to amino acids 210-254 of Human FBP3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of FBP3 (R241) pAb at 1:500 dilution Lane1:CT26 whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:HEK293T whole cell lysate(40ug) Lane4:SGC7901 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of FBP3 (R241) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.