Product Name :ALK (W1503) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :LTK, ALK and Ros have been identified as receptor tyrosine kinases having sequence similarity to the Insulin receptor subfamily of kinases. LTK, leukocyte tyrosine kinase, is expressed in murine B lymphocyte precursors and has also been found in forebrain neurons. ALK, anaplastic lymphoma kinase, is normally highly expressed specifically in the nervous system. A truncated form containing the catalytic domain of ALK is expressed as the result of a translocation occuring in many non-Hodgkin’s lymphomas. The c-Ros gene was originally identified in mutant form as an oncogene. Ros is normally expressed in a small number of epithelial cell types and may play a role in epithelial development.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :ALK (W1503) polyclonal antibody detects endogenous levels of ALK protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :ErbB HER Signaling,
Alternative Name :ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246; ALK
Immunogen :Synthetic peptide, corresponding to amino acids 1470-1523 of Human ALK.
Modification :Unmodification
