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CLC-6 (K649) polyclonal antibody

货号: BS3104
价格 1140
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS3104
Product Name :CLC-6 (K649) polyclonal antibody
Swiss-Prot :P51797
Host :Rabbit
Reactivity :Human,Mouse
Applications :WB
Application_all :WB: 1:500~1:1000
Background :The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7, 3q26, 4q32, Xp22, Xp11, 1p36 and 16p13, respectively. CLC-1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC-1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC-2 is highly expressed in the epithelia of several organs including lung, which suggests CLC-2 may be a possible therapeutic target for cystic fibrosis. CLC-3 expression is particularly abundant in neuronal tissue, while CLC-4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC-5 lead to Dent’s disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC-6 and CLC-7 are broadly expressed in several tissues including testes, kidney, brain and muscle.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :CLC-6 (K649) polyclonal antibody detects endogenous levels of CLC-6 protein.
BiowMW :~ 90 kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Chloride transport protein 6; Chloride channel protein 6; ClC-6; CLCN6; KIAA0046
Immunogen :Synthetic peptide, corresponding to amino acids 620-680 of Human CLC-6.
Conjugate :Unconjugated
Modification :Unmodification
Western blot (WB) analysis of CLC-6 (K649) polyclonal antibody in extracts from HEK293A cells.

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com