产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

GPR91 (A135) polyclonal antibody

货号: BS2961

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2961

Product Name :GPR91 (A135) polyclonal antibody

Swiss-Prot :Q9BXA5

Host :Rabbit

Reactivity :Human

Applications :WB IF

Application_all :WB: 1:500~1:1000 IF: 1:50~1:200

Background :GPR91 (formerly known as P2U2) is a G protein-coupled, dicarboxylic acid succinate receptor. It has a high level of expression in the kidney, predominantly in the proximal tubules, and localizes to the plasma membrane. It has also been found at low levels in the liver and the spleen. GPR91 functions as a citric acid cycle intermediate succinate receptor. Two signaling pathways result from GPR91 activation, the pertussis-toxin-sensitive Gi/Go pathway and the pertussis-toxin-insensitive Gq pathway. Four amino acid residues are necessary for GPR91 activation by succinate: Arg 99, His 103, Arg 252 and Arg 281. GPR91 plays an important role in the succinate-induced hypertensive effect and may be involved in renovascular hypertension, a disease linked to diabetes, renal failure and atherosclerosis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :GPR91 (A135) polyclonal antibody detects endogenous levels of GPR91 protein.

BiowMW :~ 38 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :G-protein coupled receptor 91; P2Y purinoceptor 1-like; SUCNR1; GPR91

Immunogen :Synthetic peptide, corresponding to Human GPR91.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of GPR91 expression in H1792 (A), SHSY5Y (B)whole cell lysates.

Immunofluorescence analysis of MCF-7 cells using GPR91 pAb at dilution of 1:50.

Succinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: Therapeutic effects of ginsenoside Rb1

JournalBiochimica Et Biophysica Acta-Molecular Basis Of Disease

ApplicationIF,WB

IF4.328

SpeciesMouse,Rat

PMID28736181
Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1α/VEGF axis

JournalFree Radical Biology And Medicine

ApplicationWB,IF,IHC

IF6.17

SpeciesRat,Human

PMID30030103