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GCSm-γ (V91) polyclonal antibody（KU）

货号: BS2927

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS2927

Product Name :GCSm-γ (V91) polyclonal antibody（KU）

Swiss-Prot :P48507

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Gamma-glutamylcysteine synthetase (γ-GCS) is the rate limiting enzyme for glutathione (L-γ-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. γ-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic ntioxidants, heat shock, oxidants and cytokines. The human γ-GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human γ-GCS gene encoding the regulatory subunit maps to chromosome 1p22-p21. The two subunits of γ-GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :GCSm-γ (V91) polyclonal antibody detects endogenous levels of GCSm-γ protein.

BiowMW :~ 30 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Glutamate--cysteine ligase regulatory subunit; GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit; GLCLR; GCLM

Immunogen :Synthetic peptide, corresponding to amino acids 50-100 of Human GCSm-γ.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of GCSm-γ (V91) pAb at 1:500 dilution Lane1:MEF whole cell lysate(40ug) Lane2:The Spleen tissue lysate of Mouse(40ug) Lane3:HEK293T whole cell lysate(40ug) Lane4:Panc1 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of GCSm-γ (V91) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.

Neuroprotective effect of Ginsenoside Re against neurotoxin‑induced Parkinson's disease models via induction of Nrf2

JournalMolecular Medicine Reports

ApplicationWB

IF2.952

SpeciesHuman

PMID35543148