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Acrp30 (R55) polyclonal antibody（KU）

货号: BS2833

价格：￥ 660

货期：现货（1-2个工作日）

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No. :BS2833

Product Name :Acrp30 (R55) polyclonal antibody（KU）

Swiss-Prot :Q15848

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Adiponectin, also termed AdipoQ, Acrp30, apM1 and GBP28, is an adipokine expressed exclusively in brown and white adipocytes. It is secreted into the blood and exists in three major forms: a low molecular weight trimer, a medium molecular weight hexamer and a high molecular weight multimer. Adiponectin levels are decreased in obese and insulin-resistant mice and humans, suggesting that this adipokine is critical to maintain insulin sensitivity. Adiponectin stimulates the phosphorylation of AMPKα at Thr172 and activates AMPK in skeletal muscle. It also stimulates glucose uptake in myocytes. The block of AMPK activation by a dominant-negative AMPKα2 isoform inhibits the effect of adiponectin on glucose uptake, indicating that adiponectin stimulates glucose uptake and increases insulin sensitivity through its action on AMPK. Adiponectin mutants that are not able to form oligomers larger than trimers have no effect on the AMPK pathway. Mutations that render adiponectin unable to form high molecular weight multimers are associated with human diabetes, indicating the importance of multimerization for adiponectin activity.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Acrp30 (R55) polyclonal antibody detects endogenous levels of Acrp30 protein.

BiowMW :~ 27 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Adiponectin; 30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein; ACRP30; Adipocyte; C1q and collagen domain-containing protein; Adipose most abundant gene transcript 1 protein; apM-1; Gelatin-binding protein; ACDC; ACRP30; APM1; GBP28; ADIPOQ

Immunogen :Synthetic peptide, corresponding to amino acids 22-76 of Human Acrp30.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Acrp30 (R55) polyclonal antibody at 1:1000 dilution Lane1:MCF-7 whole cell lysate(40ug) Lane2:The testis tissue lysate of Mouse(40ug) Lane3:The liver tissue lysate of Rat(40ug)

Chrysin attenuates inflammation by regulating M1/M2 status via activating PPARγ

JournalBiochemical Pharmacology

ApplicationWB

IF4.825

SpeciesMouse

PMID24704474
Lipopolysaccharide challenge significantly influences lipid metabolism and proteome of white adipose tissue in growing pigs

JournalLipids in Health and Disease

ApplicationWB

IF3.876

SpeciesPig

PMID