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Frizzled-7 (Y87) polyclonal antibody（KU）

货号: BS2774

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS2774

Product Name :Frizzled-7 (Y87) polyclonal antibody（KU）

Swiss-Prot :O75084

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IP

Application_all :WB: 1:500~1:2000 IP: 1:50~1:200

Background :The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled, as well as several secreted mammalian frizzled-related proteins: FRP-1 (also designated SARP2), FRP-2 (also designated SARP1), FRP-3, FRP-4 and SARP3 (also designated FRP-5), have been identified. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt. frizzled-7 has a Lys-Thr-X-X-X-Trp motif which is involved in the activation of the Wnt/beta-catenin signaling pathway. frizzled-7 is an integral membrane protein showing a high expression in adult skeletal muscle, fetal kidney, fetal lung, adult heart, brain and placenta. It is specifically expressed in squamous cell esophageal carcinomas.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Frizzled-7 (Y87) polyclonal antibody detects endogenous levels of Frizzled-7 protein.

BiowMW :~ 70 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Frizzled7; Frizzled 7; Fz-7; hFz7; FzE3; FZD7

Immunogen :Synthetic peptide, corresponding to amino acids 61-110 of Human Frizzled-7.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of Frizzled-7 (Y87) pAb at 1:500 dilution Lane1:Hela whole cell lysate(30ug) Lane2:BV2 whole cell lysate(30ug) Lane3:PC12 whole cell lysate(30ug)

Short hairpin RNA silencing of TGF-βRII and FZD-7 synergistically suppresses proliferation and metastasis of hepatocellular carcinoma cells

JournalOncology Letters

ApplicationWB

IF2.967

SpeciesHuman

PMID
Downregulation of Frizzled-7 induces the apoptosis of hepatocellular carcinoma cells through inhibition of NF-κB

JournalOncology Letters

ApplicationWB

IF2.311

SpeciesHuman

PMID29731900
N-glycosylation of Wnt3 regulates the progression of hepatocellular carcinoma by affecting Wnt/β-catenin signal pathway

JournalWorld Journal of Gastrointestinal Oncology

ApplicationWB

IF2.5

SpeciesHuman

PMID38994173