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Frizzled-5/8 (W73) polyclonal antibody（KU）

货号: BS2700

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2700

Product Name :Frizzled-5/8 (W73) polyclonal antibody（KU）

Swiss-Prot :Q9H461/Q13467

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF

Application_all :WB: 1:1000~1:2000 IF: 1:100~1:500

Background :Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Frizzled-8 polyclonal antibody detects endogenous levels of Frizzled-8 protein.

BiowMW :~ 73 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Fz-8; hFz8; FZD8; FZ-8; hFZ8; Frizzled 8; Frizzled8

Immunogen :Synthetic peptide, corresponding to Human Frizzled-8.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of Frizzled-8 (FZD8) at 1:1000 dilution Lane1:HEK293T whole cell lysate(30ug) Lane2:A549 whole cell lysate(30ug) Lane3:The Stomach tissue lysate of Mouse(30ug) Lane4:The Spleen tissue lysate of Rat(30ug) Lane5:BV2 whole cell lysate(30ug) Lane6:PC12 whole cell lysate(30ug)