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CXCR7 (A356) polyclonal antibody

货号: BS2694

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS2694

Product Name :CXCR7 (A356) polyclonal antibody

Swiss-Prot :P25106

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Members of the C-X-C or α chemokine family are characterized by a pair of cysteine residues separated by a single amino acid and primarily function as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 (SDF-1). Receptors for the C-X-C family are G protein-coupled, seven pass transmembrane domain proteins and include proteins such as IL-8RA, IL-8RB, CXCR-3 and fusin (also designated LESTR or CXCR-4). C-X-C chemokine receptor type 7 (CXCR-7), also known as RDC-1, is a 362 amino acid receptor for SDF-1. Initially identified as a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor. CXCR-7, with CSCR-4, also acts as a co receptor for human immunodeficiency viruses (HIV). Highly expressed in monocytes, B cells and basophils, and highly active in various biological processes, including cell growth, cell adhesion and tumor growth, CXCR-7 may play a role in tumorigenesis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CXCR7 (A356) polyclonal antibody detects endogenous levels of CXCR7 protein.

BiowMW :~ 41 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1; CXCR 7; CMKOR1; GPR159; RDC1

Immunogen :Synthetic peptide, corresponding to amino acids 325-375 of Human CXCR7.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CXCR7 (A356) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:Panc1 whole cell lysate(40ug) Lane3:C0S-7 whole cell lysate(40ug) Lane4:U-87MG whole cell lysate(40ug) Lane5:K562 whole cell lysate(40ug) Lane6:BV2 whole cell lysate(40ug) Lane7:PC12 whole cell lysate(40ug) Lane8:CT26 whole cell lysate(40ug)

Oroxylin A reverses the drug resistance of chronic myelogenous leukemia cells to imatinib through CXCL12/CXCR7 axis in bone marrow microenvironment

JournalMolecular Carcinogenesis

ApplicationWB

IF3.411

SpeciesHuman

PMID27533597
Wogonin reverses the drug resistance of chronic myelogenous leukemia cells to imatinib through CXCL12-CXCR4/7 axis in bone marrow microenvironment

JournalAnnals of Translational Medicine

ApplicationIHC,WB

IF3.297

SpeciesMouse,Human

PMID33145265