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ADORA3 (E318) polyclonal antibody（KU）

货号: BS2583

价格：￥ 660

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS2583

Product Name :ADORA3 (E318) polyclonal antibody（KU）

Swiss-Prot :P33765

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :IHC IF

Application_all :IHC: 1:50~1:200 IF: 1:50~1:200

Background :Adenosine is involved in a variety of processes, including the synthesis of urea, the anti-inflammatory response and the inhibition of protein synthesis The adenosine receptors, including adenosine A1-R, adenosine A2A-R, adenosine A2B-R and adenosine A3-R, are integral membrane proteins that are members of the G protein-coupled receptor family. The A1-R protein mediates ureagenesis in a partially calcium-dependent manner. Adenosine is known to mediate coronary vasodilation via the A2A-R receptor. Collagen synthesis and total protein synthesis are inhibited in certain cells by adenosine, acting via the A2B receptors. Activation of the A3-R receptor inhibits the induction of the cytokine TNFα and blocks the endotoxin CD14 receptor signal transduction pathway.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ADORA3 (E318) polyclonal antibody detects endogenous levels of Adenosine receptor A3 protein.

BiowMW :~ 38 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ADORA3; ORF Names: UNQ1931/PRO4406; Adenosine receptor A3; Adenosine A3-R

Immunogen :Synthetic peptide, corresponding to amino acids C-terminus of Human ADORA3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ADORA3 pAb at 1:500 dilution Lane1:C6 whole cell lysate(40ug) Lane2:SHSY5Y whole cell lysate(40ug) Lane3:SP2/0 whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug) Lane5:Jurkat whole cell lysate (40ug)

Immunohistochemistry (IHC) analyzes of ADORA3 (E318) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50,showing cytoplasm and membrane staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Cisplatin decreases cyclin D2 expression via upregulating miR‑93 to inhibit lung adenocarcinoma cell growth

JournalMolecular Medicine Reports

ApplicationWB

IF1.851

SpeciesMouse,Human

PMID31432162