Product Name :CLK1 (R126) polyclonal antibody
Application_all :WB: 1:500~1:1000
IHC: 1:50~1:200
Background :The CDC-like kinase 1 (CLK1) dually phosphorylates serine and arginine rich proteins of the spliceosomal complex, which constitutes a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Specifically, CLK1 may mediate the release of specific proteins from nuclear storage sites. Expression of CLK1 may be very low due to a premature stop codon in the mRNA, which leads to nonsense-mediated mRNA decay. CLK1 activity is positively regulated by phosphorylation on either tyrosine residues or serine/ threonine residues, and is negatively regulated by steric constraints mediated by the N-terminal domain, and also by phosphorylation on a subset of serine/threonine residues within the catalytic domain.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :CLK1 (R126) polyclonal antibody detects endogenous levels of CLK1 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Dual specificity protein kinase CLK1; CDC-like kinase 1; CLK1; CLK
Immunogen :Synthetic peptide, corresponding to amino acids 100-150 of Human CLK1.
Modification :Unmodification
