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AIM2 (A78) polyclonal antibody（KU）

货号: BS2393

价格：￥ 660

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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详细信息检测数据实验指南文献

No. :BS2393

Product Name :AIM2 (A78) polyclonal antibody（KU）

Swiss-Prot :O14862

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :IHC

Application_all :WB: 1:500~1:1000

Background :Interferon-inducible protein AIM2 (absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-γ, AIM2 is thought to act as a tumor suppressor by repressing NFκB transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of α-helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of caspase-1. AIM2 is present as a homodimer and is expressed highly in small intestine, testis, peripheral blood leukocytes and spleen. Defects in AIM2 are believed to be a cause of microsatellite unstable colon cancers.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AIM2 (A78) polyclonal antibody detects endogenous levels of AIM2 protein.

BiowMW :~ 39 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Inflammasonme Signaling,

Alternative Name :Interferon-inducible protein AIM2; Absent in melanoma 2

Immunogen :Synthetic peptide, corresponding to amino acids 51-100 of Human AIM2.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of AIM2 (A78) pAb at 1:500 dilution Lane1:K562 whole cell lysate(40ug) Lane2:HCT116 whole cell lysate(40ug) Lane3:SGC7901 whole cell lysate(40ug)