Product Name :Actinin-α1/2/3/4 (W48) polyclonal antibody（KU）
Swiss-Prot :P12814/P35609/Q08043/O43707
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
IHC: 1:50~1:200
Background :The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and α-actinins. There are four tissue-specific α-actinins, namely α-actinin-1, α-actinin-2, α-actinin-3 and α-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each α-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding α-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Actinin-α1/2/3/4 (W48) polyclonal antibody detects endogenous levels of total α-actinin protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :pan-α-Actinin; α-Actinin-pan; Actinin-α; Actinin α; α Actinin; α-Actinin; Alpha-actinin-4; F-actin cross-linking protein; Non-muscle alpha-actinin 4; ACTN4; α-Actinin4; Actinin α4; Actininα4; αActinin-4; Actinin-α4; α-actinin-4; Alpha-actinin-1; Alpha-actinin cytoskeletal isoform; Non-muscle alpha-actinin-1; ACTN1; α-Actinin1; Actinin α1; Actininα1; αActinin-1; Actinin-α1; α-actinin-1; Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; ACTN2; α-Actinin2; Actinin α2; Actininα2; αActinin-2; Alpha-actinin-3; Alpha-actinin skeletal muscle isoform 3; ACTN3; α-Actinin3; Actinin α3; Actininα3; αActinin-3; Actinin-α3; α-actinin-2; α-actinin-3
Immunogen :Synthetic peptide, corresponding to amino acids 30-60 of Human Actinin-α1.
Modification :Unmodification
