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CYP17A1 (N249) polyclonal antibody(KU)

货号: BS2187
价格 1140
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS2187
Product Name :CYP17A1 (N249) polyclonal antibody(KU)
Swiss-Prot :P05093
Host :Rabbit
Reactivity :Human
Applications :WB IHC IF
Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Background :CYP17A (17α-hydroxylase/17,20-lyase) is important for the conversion of pregnenolone and progesterone to dehydroepiandrosterone (DHEA) and androstenedione. In this process, it catalyzes both the 17α-hydroxylation and the 17,20-lyase reaction.CYP17A1 is crucial during sexual development, both during fetal development and during puberty, and is intracellularly regulated by cAMP levels. Defects in the CYP17A1 gene, which encodes for the protein, may cause adrenal hyperplasia type V (AH-V) which is characterized by hypokalemia and hypertension.Male patients affected by AH-V do not undergo normal sexual differentiation and develop female external genitalia and do not undergo pubertal develoment.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :CYP17A1 (N249) polyclonal antibody detects endogenous levels of CYP17A1 protein.
BiowMW :~ 57 kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Steroid 17-alpha-hydroxylase/17,20 lyase; 17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase; CYP17A1; CYP17; S17AH
Immunogen :Synthetic peptide, corresponding to amino acids 211-260 of Human CYP17A1.
Conjugate :Unconjugated
Modification :Unmodification
Western blot (WB) analysis of CYP17A1 (N249) pAb at 1:500 dilution Lane1:MCF-7 whole cell lysate(40ug) Lane2:A2780 whole cell lysate(40ug) Lane3:PC3 whole cell lysate(40ug) Lane4:HEK293T whole cell lysate(40ug)
Immunohistochemistry (IHC) analyzes of CYP17A1 (N249) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com