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ERAP1 (K467) polyclonal antibody（KU）

货号: BS2155

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2155

Product Name :ERAP1 (K467) polyclonal antibody（KU）

Swiss-Prot :Q9NZ08

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) is a 120 kDa protein localized to the lumen of the ER, which removes NH2-terminal residues from many antigenic precursors for MHC class I peptide presentation. Peptides that are presented by MHC class I on the surface of a cell must be 8-11 residues long, and ERAP1 specifically trims peptides of 9 amino acids or more. ERAP1 is also induced by interferon-γ. The gene encoding human ERAP1 maps to chromosome 5q15. ERAP1 has previously been characterized as adipocyte-derived leucine aminopeptidase (A-LAP), puromycin-insensitive leucine-specific aminopeptidase (PILS-AP) and aminopeptidase regulator of TNFR1 shedding (ARTS-1). A-LAP is thought to inactivate several bioactive peptides, including angiotensin II and, subsequently, may be involved in the regulation of blood pressure. PILS-AP is described as playing a role in angiogenesis by regulating the proliferation and migration of endothelial cells, and ARTS-1 is characterized as a TNFR1 binding protein that promotes TNFR1 shedding. Further research will be necessary to fully elucidate the functions of this protein.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ERAP1 (K467) polyclonal antibody detects endogenous levels of ERAP1 protein.

BiowMW :~ 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Endoplasmic reticulum aminopeptidase 1; ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator; ERAP1; APPILS; ARTS1, KIAA0525; UNQ584/PRO1154

Immunogen :Synthetic peptide, corresponding to amino acids 435-489 of Human ERAP1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ERAP1 (K467) pAb at 1:500 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(20ug) Lane3:PC12 whole cell lysate(20ug) Lane4:AML-12 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of ERAP1 (K467) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

ERp44 Exerts Redox-Dependent Control of Blood Pressure at the ER

JournalMolecular Cell

ApplicationWB,IP

IF17.97

SpeciesHuman

PMID25959394
Sex-specific differences in endoplasmic reticulum aminopeptidase 1 modulation influence blood pressure and renin-angiotensin system responses

JournalJCI Insight

ApplicationWB

IF8.315

SpeciesMouse

PMID31672933