产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

HPK1 (L397) polyclonal antibody（KU）

货号: BS2115

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2115

Product Name :HPK1 (L397) polyclonal antibody（KU）

Swiss-Prot :Q92918

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Several mammalian kinases have been identified with sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase STE20. STE20 is involved in relaying signals from G protein coupled receptors to cytosolic MAP kinase cascades, and it lies upstream of a MAP kinase kinase kinase. Mammalian STE20-like kinases include HPK1, KHS, GLK, NIK, YSK1, Krs-1, Krs-2 and GC kinase. HPK1 (hematopoietic progenitor kinase 1), like many other STE20-like kinases, specifically activates the JNK signaling pathway. HPK1 binds to and phosphorylates MEKK, suggesting it plays an important role in regulating the stress responsive JNK/SAPK signaling pathway.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HPK1 (L397) polyclonal antibody detects endogenous levels of HPK1 protein.

BiowMW :~ 97 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :SAPK JNK Signaling Cascades,

Alternative Name :Mitogen-activated protein kinase kinase kinase kinase 1; Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; MAP4K1; HPK1

Immunogen :Synthetic peptide, corresponding to amino acids 365-412 of Human HPK1.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of HPK1 (L397) pAb at 1:500 dilution Lane1:HCC827 whole cell lysate(40ug) Lane2:MCF-7 whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:H9C2 whole cell lysate(40ug) Lane5:The Spleen tissue lysate of Mouse(40ug)

Western blot (WB) analysis of HPK1 (L397) pAb at 1:500 dilution Lane1:A549 whole cell lysate(40ug) Lane2:MCF-7 whole cell lysate(40ug) Lane3:K562 whole cell lysate(40ug) Lane4:RAW264.7 whole cell lysate(40ug) Lane5:H9C2 whole cell lysate(40ug)