Product Name :HNF4α/γ (K127) polyclonal antibody（KU）
Swiss-Prot :P41235/Q14541
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
IHC: 1:50~1:200
Background :HNF-1 (α and β), HNF-3 (α, β and γ), HNF-4 (α and γ), and HNF-6 compose, in part, a homoeprotein family designated the Hepatocyte Nuclear Factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. HNF-3α, HNF-3β and HNF-3γ regulate the transcription of numerous hepatocyte genes in adult liver. HNF-3α and HNF-3β have also been shown to be involved in gastrulation events such as body axis formation. HNF-4α and HNF-4γ have been shown to be important for early embryo development. HNF-4α is expressed in liver, kidney, pancreas, small intestine, testis and colon; and HNF-4γ is expressed in each of these tissues except liver.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :HNF-4α/γ (K127) polyclonal antibody detects endogenous levels of HNF-4α and HNF-4γ protein.
BiowMW :~ 46(HNF4γ), 53(HNF4α) kDa
Note :For research use only, not for use in diagnostic procedure.
Pathway :Nuclear Receptor Signaling,
Alternative Name :Hepatocyte nuclear factor 4-alpha; HNF-4-alpha; Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4; HNF4A; HNF4; NR2A1; TCF14; Hepatocyte nuclear factor 4-gamma; HNF-4-gamma; Nuclear receptor subfamily 2 group A member 2; HNF4G; NR2A2; HNF4γ; HNF-4γ; HNF-4α
Immunogen :Synthetic peptide, corresponding to amino acids 100-150 of Human HNF4α.
Modification :Unmodification
