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ERCC5/XPG (E160) polyclonal antibody（KU）

货号: BS1973

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1973

Product Name :ERCC5/XPG (E160) polyclonal antibody（KU）

Swiss-Prot :P28715

Host :Rabbit

Reactivity :Human

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Seven complementation groups (A-G) of xeroderma pigmentosum have been described. The xeroderma pigmentosum group A protein, XPA, is a zinc metalloprotein which preferentially binds to DNA damaged by ultraviolet (UV) radiation and chemical carcinogens. XPA is a DNA repair enzyme that has been shown to be required for the incision step of nucleotide excision repair. XPG (also designated ERCC5) is an endonuclease that makes the 3’ incision in DNA nucleotide excision repair. Mammalian XPG is similar in sequence to yeast RAD2. Conserved residues in the catalytic center of XPG are important for nuclease activity and function in nucleotide excision repair.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :XPG (E160) polyclonal antibody detects endogenous levels of XPG protein.

BiowMW :~ 133, 200 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :COFS 3; COFS3; DNA excision repair protein ERCC 5; DNA excision repair protein ERCC-5; ERCC 5; ERCC5; ERCC5; ERCM 2; ERCM2; Excision Repair Cross Complementing Rodent Repair Deficiency; XPG; XPG complementing protein; XPGC;

Immunogen :Synthetic peptide, corresponding to amino acids 130-180 of Human ERCC5/XPG.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ERCC5/XPG (E160) pAb at 1:1000 dilution Lane1:PC3 whole cell lysate(40ug) Lane2:SGC7901 whole cell lysate(20ug) Lane3:HCT116 whole cell lysate(20ug)

Immunohistochemistry (IHC) analyzes of ERCC5/XPG (E160) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.