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HXK I (F67) polyclonal antibody（KU）

货号: BS1947

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1947

Product Name :HXK I (F67) polyclonal antibody（KU）

Swiss-Prot :P19367

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HXK I (F67) polyclonal antibody detects endogenous levels of HXK I protein.

BiowMW :~ 102 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Warburg Effect,Insulin &Glucose Signaling,Glutamine Metabolism,

Alternative Name :Hexokinase-1; Hexokinase 1; Brain form hexokinase; Hexokinase type I; HK I; HK1

Immunogen :Synthetic peptide, corresponding to amino acids 30-80 of Human HXK I.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of HXK I (F67) pAb at 1:500 dilution Lane1:U-87MG whole cell lysate(40ug) Lane2:C6 whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug) Lane4:MEF whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of HXK I (F67) pAb in paraffin-embedded human colorectal cancer carcinoma tissue at 1:100.