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Fra-1 (D134) polyclonal antibody（KU）

货号: BS1933

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1933

Product Name :Fra-1 (D134) polyclonal antibody（KU）

Swiss-Prot :P15407

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. Members of the c-Fos gene family, including c-Fos, Fos B, Fra-1 and Fra-2, encode nuclear phosphoproteins that are rapidly and transiently induced by a variety of agents and function as transcriptional regulators for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers that bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Fra-1 (D134) polyclonal antibody detects endogenous levels of Fra-1 protein.

BiowMW :~ 30, 42 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Fos-related antigen 1; FRA-1; FOSL1; FRA1

Immunogen :Synthetic peptide, corresponding to amino acids 100-150 of Human Fra-1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Fra-1 (D134) pAb at 1:500 dilution Lane1:PC3 whole cell lysate(40ug) Lane2:HepG2 whole cell lysate(40ug) Lane3:The Brain tissue lysate of Mouse(40ug) Lane4:PC12 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Fra-1 (D134) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.