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hnRNP Q (E268) polyclonal antibody（KU）

货号: BS1885

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1885

Product Name :hnRNP Q (E268) polyclonal antibody（KU）

Swiss-Prot :O60506

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is involved in RNA processing and is necessary for efficient pre-mRNA splicing. hnRNP is widely expressed and developmentally regulated. hnRNP Q interacts with survival motor neuron protein (SMN). Loss of function of SMN results in spinal muscular atrophy, a common neurodegenerative disease. The most common deletion in SMN genes disrupts the interaction between SMN and hnRNP Q. hnRNP Q is upregulated after midnight, and this upregulation correlates with an abrupt decline in AANAT, the key enzyme in melatonin synthesis. Rhythmic AANAT mRNA degradation mediated in part by hnRNP Q implicates this enzyme in the regulation of circadian oscillation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :hnRNP Q (E268) polyclonal antibody detects endogenous levels of hnRNP Q protein.

BiowMW :~ 65-82 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin-binding, cytoplasmic RNA-interacting protein; SYNCRIP; HNRPQ; NSAP1

Immunogen :Synthetic peptide, corresponding to amino acids 241-290 of Human hnRNP Q.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of hnRNP Q (E268) pAb at 1:500 dilution Lane1:U-87MG whole cell lysate(10ug) Lane2:HCT116 whole cell lysate(10ug) Lane3:C6 whole cell lysate(40ug) Lane4:CT26 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of hnRNP Q (E268) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.