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AKAP 10 (R27) polyclonal antibody（KU）

货号: BS1877

价格：￥ 660

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1877

Product Name :AKAP 10 (R27) polyclonal antibody（KU）

Swiss-Prot :O43572

Host :Rabbit

Reactivity :Human

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :AKAP 10 (A kinase anchor protein 10), also known as PRKA10 or D-AKAP2 (dual-specific A kinase-anchoring protein 2), is a 662 amino acid mitochondrial membrane protein that belongs to the AKAP family. AKAP 10 is a dual specificity protein that binds to both type I and type II regulatory subunits of PKA and anchors them to the plasma membrane or the mitochondria. When anchored to the mitochondria, PKA can phosphorylate and, thus, inactivate the proapoptotic protein Bad. This suggests that AKAP 10 indirectly regulates Bad-induced apoptosis by mediating the mitochondrial attachment of PKA. Additionally, AKAP 10 may facilitate G-protein coupled signal transduction and could act as an adaptor in the assembly of multiprotein complexes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AKAP 10 (R27) polyclonal antibody detects endogenous levels of AKAP 10 protein.

BiowMW :~ 74 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :A-kinase anchor protein 10, mitochondrial; AKAP-10; Dual specificity A kinase-anchoring protein 2; D-AKAP-2; Protein kinase A-anchoring protein 10; PRKA10; AKAP10

Immunogen :Synthetic peptide, corresponding to amino acids 1-50 of Human AKAP 10.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of AKAP 10 (R27) pAb at 1:500 dilution Lane1:PC3 whole cell lysate(40ug) Lane2:SGC7901 whole cell lysate(40ug) Lane3:HCT116 whole cell lysate(40ug) Lane4:Panc1 whole cell lysate(40ug) Lane5:HEK293T whole cell lysate(40ug)