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Fos B (S23) polyclonal antibody

货号: BS1645

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1645

Product Name :Fos B (S23) polyclonal antibody

Swiss-Prot :P53539

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF

Application_all :WB: 1:500~1:1000 IF: 1:50~1:200

Background :Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ‘leucine-zipper’ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :FosB (S23) polyclonal antibody detects endogenous levels of FosB protein.

BiowMW :~ 35 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Protein fosB; G0/G1 switch regulatory protein 3; FOSB; G0S3

Immunogen :Synthetic peptide, corresponding to amino acids N-terminus of Human Fos B.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Fos B (S23) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:sp2/0 whole cell lysate Lane3:PC12 whole cell lysate

Immunohistochemistry (IHC) analyzes of FosB (S23) pAb in paraffin-embedded human prostate carcinoma tissue.