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FAK (I401) polyclonal antibody（KU）

货号: BS1641

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1641

Product Name :FAK (I401) polyclonal antibody（KU）

Swiss-Prot :Q05397

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Focal adhesion kinase was initially identified as a major 125 kDa substrate for the intrinsic protein tyrosine kinase activity of Src-encoded pp60. The deduced amino acid sequence of FAK p125 has shown it to be a cytoplasmic protein tyrosine kinase whose sequence and structural organization are unique as compared to other proteins described to date. Localization of p125 by immunofluorescence suggests that it is primarily found in cellular focal adhesions leading to its designation as focal adhesion kinase (FAK). FAK is concentrated at the basal edge of only basal keratinocytes that are actively migrating and rapidly proliferating in repairing burn wounds, and is activated and localized to the focal adhesions of spreading keratinocytes in culture.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :FAK (I401) polyclonal antibody detects endogenous levels of FAK protein.

BiowMW :~ 99, 119 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics,Tumor Angiogenesis,Contribution of ECM and Cytoskeletal Factors to EMT,G Protein-coupled Receptors Signaling to MAPK Erk,

Alternative Name :Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK; PTK2; FAK; FAK1

Immunogen :Synthetic peptide, corresponding to amino acids 370-420 of Human FAK.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of FAK (I401) polyclonal antibody at 1:500 dilution Lane1:L02 whole cell lysate(40ug) Lane2:U251 whole cell lysate(40ug) Lane3:NIH-3T3 whole cell lysate(40ug) Lane4:C6 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of FAK (I401) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.