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Gab1 (E655) polyclonal antibody（KU）

货号: BS1539

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1539

Product Name :Gab1 (E655) polyclonal antibody（KU）

Swiss-Prot :Q13480

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Gab 1 (GRB2-associated binder 1), one such member of the IRS family, plays an important role in cellular growth response, transformation and apoptosis. Gab 1 is a multi-substrate docking protein that functions downstream in the signaling pathways of different receptor kinases, including EGFR. Gab1 is tyrosine phosphorylated normally in response to insulin and consequently enhances phosphatidylinositol 3- kinase (PI3K) binding. In response to osmotic shock, tyrosine-phosphorylated Gab 1 (p-Gab 1) also binds and activates phosphatidylinositol 3-kinase, suggesting that Gab 1 is the major site for PI3K recruitment following osmotic shock stimulation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Gab1 (E655) polyclonal antibody detects endogenous levels of Gab1 protein.

BiowMW :~ 76, 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1; GAB1

Immunogen :Synthetic peptide, corresponding to amino acids 622-672 of Human Gab1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Gab1 (E655) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:NIH-3T3 whole cell lysate Lane3:H9C2 whole cell lysate

Immunohistochemistry (IHC) analyzes of Gab1 (E655) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.