Product Name :ERα (K531) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
IF: 1:50~1:200
Background :Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor uperfamily of ligand-activated transcription factors. Estrogen receptors, ncluding ERα and ERβ, contain DNA binding and ligand binding domains nd are critically involved in regulating the normal function of reproductive issues. ERα and ERβ have been shown to be differentially activated by various igands. Receptor-ligand interactions trigger a cascade of events, including issociation from heat shock proteins, receptor dimerization, phosphorylation nd the association of the hormone activated receptor with specific regulatory lements in target genes. Evidence suggests that ERα and ERβ may be egulated by distinct mechanisms even though they share many functional characteristics.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :ER-α (K531) polyclonal antibody detects endogenous levels of ER-α protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Nuclear Receptor Signaling,
Alternative Name :Estrogen receptor; ER-alpha; ER; ESR1; ESR; NR3A1
Immunogen :Synthetic peptide, corresponding to amino acids 501-550 of Human ERα.
Modification :Unmodification
