产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Arrestin-β-1 (E406) polyclonal antibody

货号: BS1509

价格：￥ 660

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1509

Product Name :Arrestin-β-1 (E406) polyclonal antibody

Swiss-Prot :P49407

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :IHC IF

Application_all :IHC: 1:50~1:200 IF: 1:50~1:200

Background :Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Arrestin-β-1 (E406) polyclonal antibody detects endogenous levels of Arrestin-β-1 protein.

BiowMW :~ 51 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Hedgehog Signaling,

Alternative Name :ARB 1; ARB1; ARR 1; ARR1; ARRB 1; ARRB1; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-arrestin-1; Arrestin-β1; Arrestin β1; β-arrestin-1

Immunogen :Synthetic peptide, corresponding to amino acids 390-440 of Human Arrestin-β-1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ARRB1 pAb at 1:2000 dilution Lane1:A549 whole cell lysate(40ug) Lane2:The Brain tissue lysate of Mouse(30ug) Lane3:The Brain tissue lysate of Rat(40ug) Lane4:Panc1 whole cell lysate(40ug) Lane5:HEK293T whole cell lysate(40ug) Lane6:C6 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Arrestin-β-1 (E406) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.