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Integrin β1 (Y783) polyclonal antibody

货号: BS1444

价格：￥ 660

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1444

Product Name :Integrin β1 (Y783) polyclonal antibody

Swiss-Prot :P05556

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16 α and 8 β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ITGB1 (Y783) polyclonal antibody detects endogenous levels of ITGB1 protein.

BiowMW :~ 115 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics,Tumor Angiogenesis,Contribution of ECM and Cytoskeletal Factors to EMT,

Alternative Name :Integrin beta-1; Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit beta; CD29; ITGB1; FNRB; MDF2; MSK12

Immunogen :Synthetic peptide, corresponding to amino acids 741-790 of Human Integrin β1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ITGB1 pAb at 1:500 dilution Lane1:U-87MG whole cell lysate(40ug) Lane2:A375 whole cell lysate(40ug) Lane3:The Skin tissue lysate of Rat(40ug) Lane4:CT26 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Integrin β1 (Y783) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.

Probiotic-Derived Polyphosphate Enhances the Epithelial Barrier Function and Maintains Intestinal Homeostasis through Integrin–p38 MAPK Pathway

JournalPLoS One

ApplicationIHC

IF2.74

SpeciesMouse

PMID21858054
Inhibition of hypoxia-induced epithelial mesenchymal transition by luteolin in non-small cell lung cancer cells

JournalMolecular Medicine Reports

ApplicationWB

IF2.1

SpeciesHuman

PMID22552526
Elevated expression of integrin αv and β5 subunit in laryngeal squamous-cell carcinoma associated with lymphatic metastasis and angiogenesis

JournalPathology Research And Practice

ApplicationIHC

IF2.05

SpeciesHuman

PMID23261238
Beta1 integrin inhibits apoptosis induced by cyclic stretch in annulus fibrosus cells via ERK1/2 MAPK pathway

JournalApoptosis

ApplicationIHC,WB

IF4.677

SpeciesRat

PMID