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FGFR1 (I648) polyclonal antibody（KU）

货号: BS1441

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1441

Product Name :FGFR1 (I648) polyclonal antibody（KU）

Swiss-Prot :P11362

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF

Application_all :WB: 1:500~1:1000 IF: 1:50~1:200

Background :FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family containing an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is a widely expressed membrane receptor, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :FGFR1 (I648) polyclonal antibody detects endogenous levels of FGFR1 protein.

BiowMW :~ 92, 120,145 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,

Alternative Name :Fibroblast growth factor receptor 1; FGFR-1; 2.7.10.1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr; CD331; BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR; FGFR1

Immunogen :Synthetic peptide, corresponding to amino acids 621-670 of Human FGFR1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of FGFR1/Flg (I648) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:786-0 whole cell lysate(40ug) Lane3:U-251MG whole cell lysate(40ug) Lane4:PC12 whole cell lysate(40ug) Lane5:MEF whole cell lysate(40ug)

Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation

JournalNature Communications

ApplicationWB

IF11.878

SpeciesHuman

PMID28516914
Antiarthritic Effects of Sorafenib in Rats with Adjuvant‐Induced Arthritis

JournalAnatomical Record

ApplicationWB

IF1.329

SpeciesRat

PMID29752865