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Dynamin-1 (V768) polyclonal antibody（KU）

货号: BS1396

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1396

Product Name :Dynamin-1 (V768) polyclonal antibody（KU）

Swiss-Prot :Q05193

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Members of the Dynamin family, including Dynamin I and Dynamin II, are GTPase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression in testis. Both Dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the Dynamins and effectors of their GTPase activity. The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to Clathrin coated pits by SH3 domain interaction with Amphiphysin, a protein highly expressed in brain.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Dynamin-1 (V768) polyclonal antibody detects endogenous levels of Dynamin-1 protein.

BiowMW :~ 98 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Vesicle Trafficking presynaptic signaling,

Alternative Name :Dynamin 1; Dynamin1; DNM1; DNM; Dynamin I; Dynamin-I; DynaminI

Immunogen :Synthetic peptide, corresponding to amino acids 750-800 of Human Dynamin-1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Dynamin-1 (V768) pAb at 1:500 dilution Lane1:HCT116 whole cell lysate(40ug) Lane2:MCF-7 whole cell lysate(40ug) Lane3:PC12 whole cell lysate(40ug) Lane4:CT26 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Dynamin-1 (V768) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

Molecular Mechanism of Constitutive Endocytosis of Acid-Sensing Ion Channel 1a and Its Protective Function in Acidosis-Induced Neuronal Death

JournalJournal Of Neuroscience

ApplicationWB

IF5.673

SpeciesMouse,Hamnster

PMID23595764
Proteomic Changes in Female Rat Hippocampus Following Exposure to a Terrified Sound Stress

JournalJournal Of Molecular Neuroscience

ApplicationWB

IF3.444

SpeciesRat

PMID