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Cytokeratin 5 (S573) polyclonal antibody（KU）

货号: BS1208

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1208

Product Name :Cytokeratin 5 (S573) polyclonal antibody（KU）

Swiss-Prot :P13647

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. Cytokeratin 5 is expressed in normal basal cells. Mutations of the Cytokeratin 5 gene (KRT5) have been shown to result in the autosomal dominant disorder epidermolysis bullosa (EB).

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Cytokeratin 5 (S573) polyclonal antibody detects endogenous levels of Cytokeratin 5 protein.

BiowMW :~ 62 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Contribution of Soluble Factors to EMT,

Alternative Name :Keratin, type II cytoskeletal 5; 58 kDa cytokeratin; Cytokeratin-5; Cytokeratin5; Short name=CK-5; CK5; Keratin-5; Keratin5; Keratin 5; Short name=K5; Type-II keratin Kb5; KRT5

Immunogen :Synthetic peptide, corresponding to amino acids 550-600 of Human Cytokeratin 5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Cytokeratin 5 (S573) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:NIH-3T3 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Cytokeratin 5 (S573) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma

JournalNature Communications

ApplicationIHC

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SpeciesMouse

PMID37923710
EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation

JournalJOURNAL OF EXPERIMENTAL MEDICINE

ApplicationIHC,IF,WB

IF15.3

SpeciesHuman,Mouse

PMID38284990
TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition

JournalJOURNAL OF EXPERIMENTAL MEDICINE

ApplicationIHC,IF,WB

IF15.3

SpeciesMouse

PMID38805014