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Cytokeratin 18 (T410) polyclonal antibody（KU）

货号: BS1204

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1204

Product Name :Cytokeratin 18 (T410) polyclonal antibody（KU）

Swiss-Prot :P05783

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Cytokeratin 18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.Involved in the uptake of thrombin-antithrombin complexes by hepatic cells By similarity. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Cytokeratin 18 (T410) polyclonal antibody detects endogenous levels of Cytokeratin 18 protein.

BiowMW :~ 46 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Contribution of Soluble Factors to EMT,

Alternative Name :Keratin, type I cytoskeletal 18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; Short name=CK-18; Keratin-18; Short name=K18; KRT18; CYK18; PIG46; KRT 18; CK 18; CK18; Keratin 18; Keratin18; CK-18

Immunogen :Synthetic peptide, corresponding to amino acids 381-430 of Human Cytokeratin 18.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Cytokeratin 18 (T410) polyclonal antibody at 1:500 dilution Lane1:The Liver tissue lysate of Rat(40ug) Lane2:AML-12 whole cell lysate(20ug) Lane3:HEK293T whole cell lysate(40ug) Lane4:HCT116 whole cell lysate(20ug)

Immunohistochemistry (IHC) analyzes of Cytokeratin 18 (T410) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Contribution of SATB2 to the stronger osteogenic potential of bone marrow stromal cells from craniofacial bones

JournalCell And Tissue Research

ApplicationIF

IF3.36

SpeciesRat

PMID22955562
MicroRNA-7 Inhibits Tumor Metastasis and Reverses Epithelial-Mesenchymal Transition through AKT/ERK1/2 Inactivation by Targeting EGFR in Epithelial Ovarian Cancer

JournalPLoS One

ApplicationWB

IF2.74

SpeciesHuman

PMID