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IGF-1R (G1155) polyclonal antibody（KU）

货号: BS1182

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1182

Product Name :IGF-1R (G1155) polyclonal antibody（KU）

Swiss-Prot :P08069/P06213

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IGF-1R (G1155) polyclonal antibody detects endogenous levels of IGF-1R protein. This antibody may cross-reacts with insulin receptor protein.

BiowMW :~ 95,155 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,Insulin &Glucose Signaling,

Alternative Name :Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; IGF1R

Immunogen :Synthetic peptide, corresponding to amino acids 1121-1170 of Human IGF-1R.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of IGF-1R (G1155) pAb at 1:500 dilution Lane1:AML-12 whole cell lysate(40ug) Lane2:C6 whole cell lysate(40ug) Lane3:HepG2 whole cell lysate(40ug) Lane4:Panc1 whole cell lysate(40ug) Lane5:HEK293T whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of IGF-1R (G1155) antibody in paraffin-embedded human breast carcinoma tissue.

Effects of Curcumin on Epidermal Growth Factor in Proliferative Vitreoretinopathy

JournalCellular Physiology And Biochemistry

ApplicationICC

IF0

SpeciesRabbit

PMID29975931