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HDAC 9 (P1047) polyclonal antibody（KU）

货号: BS1168

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1168

Product Name :HDAC 9 (P1047) polyclonal antibody（KU）

Swiss-Prot :Q9UKV0

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1–9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HDAC9 (P1047) polyclonal antibody detects endogenous levels of HDAC9 protein.

BiowMW :~ 120 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Cell Cycle Control G1 S Checkpoint,

Alternative Name :Histone deacetylase 9; Short name=HD9; Histone deacetylase 7B; Short name=HD7; Short name=HD7b; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR; HDAC9; HDAC7; HDAC7B; HDRP; KIAA0744; MITR

Immunogen :Synthetic peptide, corresponding to the C-terminual of Human HDAC 9.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of HDAC 9 (P1047) polyclonal antibody at 1:500 dilution Lane1:Rat Brain tissue lysate Lane2:Mouse Brain tissue lysate Lane3:SGC7901 cell lysate Lane3:HEK293T cell lysate Lane3:MCF-7 cell lysate

Immunohistochemistry (IHC) analyzes of HDAC 9 (P1047) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.